Prox Authors & Ebola
The evolution of Ebola virus: Insights from the 2013-2016 epidemic. (Nature paywall: $32 for a 6-page paper! Sponsored by Wellcome VIZIONS - how does that fit with Wellcome's policy in support of open and unrestricted access to research literature? You can buy a whole book on the outbreak by Constantine Nana for $7-8 - way more insights.)
Pub: Nature, October 2016.
InThe the2013–2016 paper,Ebola thevirus authors/Naturedisease repeat(EVD) theepidemic unprovenin claimWest thatAfrica theappears outbreakto beganhave begun following human contact with an animal (probably bat) reservoir of Ebola virus (EBOV) in December 2013, in the small village of Meliandou in Guéckédou Prefecture, Guinea.
Straight off the bat, the authors promulgate/imprint an unsubstantiated origin narrative first developed by Baize et al- the toddler, the hollow tree, in a remote village of Meliandou, Guniea - the pangolin narrative of the day. In
Oddly, for a paper titled The evolution of the Ebola virusvirus: Insights ..., they strangely skip right over any examination of this theory in the first sentences saying: the origin and spread of the 2013–2016 EVD epidemic seem well resolved.
TheyBaize's paper reports the first confirmed case was in a Health worker at Gueckedou hospital on Feb 23. It speculates about a chain of 12 unconfirmed but suspected cases going back to the bat tree - that may have lead to the first confirmed case but notes the epidemiologic links are not well established.
That's academic skulduggery by Holmes et al. The very paper they cite Baize’to say it's well resolved says it's paper,not whichwell promulgatedestablished.
Baize's not well established theory, in turn, is based on initial epidemiologic investigation that he doesn't cite but it appears to be Fabian Leendertz expedition.
Science: Soon after the outbreak was identified as Ebola in March 2014, wildlife epidemiologist Fabian Leendertz of the Robert Koch Institute in Berlin went to southeastern Guinea to look for signs of an outbreak in wildlife. Leendertz, with three more German veterinarians spent 4 weeks in the region, capturing bats from four sites and surveying two protected forest areas.
So more than 3 months after the death of the toddler.
The researchers found no evidence that wild animals were dying of Ebola, they report in a paper published online today in theEMBO Molecular Medicine. storyThe populations of achimpanzees, toddlerduikers, and other large mammals were at about the same levels they had been in the previous surveys in the region. They also found no direct evidence of Ebola virus infections in any of the 169 bats (from at least 13 species) that they captured and tested.
No evidence of any animal infection. Not that that's ever stopped a remotezoonotic villagescientist inbefore. Guinea
But Ebolatheir whenvisit playingto nearMeliandou ayielded hollowintriguing tree. clues.
Science reports that the tree mysteriously burned to a stump just before they arrived, thwarting their search for evidence that might confirm the scenario.
So convenient.
But the point is it’s unconfirmed. The search for evidence was thwarted. Then why are Andersen, Holmes, Rambaut saying the origin seems well resolved?
The narrative became well established - repeated by other researchers - who fed it to the media. Notice any similarities?
And so another origin story gets passed into science zoonosis lore - without any substantial proof.